<p> <b>Full Title</b><br> Protocol GO46021: A Phase Ib/II Multicenter, Open-label, Randomized Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-4198 Alone and in Combination With Giredestrant in Comparison With Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2-negative Breast Cancer Who Have Previously Progressed During Or After a CDK4/6 Inhibitor </p> <p> <b>Study Treatment</b><br> Oral CDK2/4/6 inhibitor GDC-4198 as monotherapy or in combination with oral next generation SERD Giredestrant </p> <p> <b>Eligibility/Info</b><br> Eligible patients must have metastatic ER+, HER2- breast cancer that has been treated with a CDK4/6 inhibitor in the metastatic setting but has not been treated with chemotherapy in the metastatic setting. </p> <p> <b>Contact</b><br> For more information about this or any other study, please contact the NYCBS Research Department:<br> Email: <a href="mailto:ResearchRecruitment@nycancer.com">ResearchRecruitment@nycancer.com</a><br> Telephone: <a href="tel:631-675-5075">631-675-5075</a><br> HALO Messaging App: "Research Team" </p> <p> <b>Locations</b><br> <a href="https://nycancer.com/locations/Babylon_Medical_Oncology">Babylon Medical Oncology</a><br> <a href="https://nycancer.com/locations/central_park_medical_oncology">Central Park Medical Oncology</a><br> <a href="https://nycancer.com/locations/eastchestercancercenter">Eastchester Cancer Center</a><br> <a href="https://nycancer.com/locations/lake_success_medical_oncology">Lake Success Medical Oncology</a><br> <a href="https://nycancer.com/locations/nostrand_medical_oncology">Nostrand Medical Oncology</a><br> <a href="https://nycancer.com/locations/Patchogue_Medical_Oncology">Patchogue Medical Oncology</a><br> <a href="https://nycancer.com/locations/Port_Jefferson_Medical_Oncology">Port Jefferson Medical Oncology</a><br> <a href="https://nycancer.com/locations/Port_Jefferson_Station_Medical_Oncology">Port Jefferson Station Medical Oncology</a><br> <a href="https://nycancer.com/locations/Riverhead_Medical_Oncology">Riverhead Medical Oncology</a><br> </p>