<p> <b>Full Title</b><br> Protocol D9722C00001: A Randomised, Open-Label, Phase III Study of Saruparib (AZD5305) Plus Camizestrant compared with Physician’s Choice CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant for the First-Line Treatment of Patients with BRCA1, BRCA2, or PALB2 Mutations and Hormone Receptor-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH non-amplified) Advanced Breast Cancer </p> <p> <b>Study Treatment</b><br> Study participant treatment will be randomized 2:2:1 between the following 3 treatment arms: <ul> <li>Arm 1: PARP1 inhibitor saruparib in combination with next generation selective estrogen receptor degrader camizestrant</li> <li>Arm 2: Physician's choice CDK4/6 inhibitor in combination with standard endocrine therapy</li> <li>Arm 3: Physician's choice CDK4/6 inhibitor in combination with camizestrant</li> </ul> </p> <p> <b>Eligibility/Info</b><br> Advanced or metastatic hormone receptor positive, HER2 negative breast cancer with a loss of function mutation in BRCA1, BRCA2, or PALB2. Participants must not have been treated with systemic anti-cancer therapy in the advanced/metastatic setting. </p> <p> <b>Contact</b><br> For more information you may contact the Research Department through the NYCBS HALO Messaging Center or call directly: <a href="tel:631-675-5075">631-675-5075</a>. </p> <p> <b>Locations</b><br> <a href="https://nycancer.com/locations/Babylon_Medical_Oncology">Babylon Medical Oncology</a><br> <a href="https://nycancer.com/locations/central_park_medical_oncology">Central Park Medical Oncology</a><br> <a href="https://nycancer.com/locations/eastchestercancercenter">Eastchester Cancer Center</a><br> <a href="https://nycancer.com/locations/lake_success_medical_oncology">Lake Success Medical Oncology</a><br> <a href="https://nycancer.com/locations/nostrand_medical_oncology">Nostrand Medical Oncology</a><br> <a href="https://nycancer.com/locations/Patchogue_Medical_Oncology">Patchogue Medical Oncology</a><br> <a href="https://nycancer.com/locations/Port_Jefferson_Medical_Oncology">Port Jefferson Medical Oncology</a><br> <a href="https://nycancer.com/locations/Port_Jefferson_Station_Medical_Oncology">Port Jefferson Station Medical Oncology</a><br> <a href="https://nycancer.com/locations/Riverhead_Medical_Oncology">Riverhead Medical Oncology</a><br> </p>